2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1900):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W1119943
    2'-OMe-8-Me-DMF-G Phosphoramidite
    2'-OMe-8-Me-DMF-G Phosphoramidite is a phosphoramidite compound containing modified guanine (G) and a dimethoxytrityl (DMT) group. 2'-OMe-8-Me-DMF-G Phosphoramidite can be used in RNA oligonucleotide synthesis.
    2'-OMe-8-Me-DMF-G Phosphoramidite
  • HY-177200
    DMT-biotinylated phosphoramidite
    DMT-biotinylated phosphoramidite is a phosphonamide acid that can be used in nucleic acid synthesis.
    DMT-biotinylated phosphoramidite
  • HY-W011793R
    4-Thiouridine (Standard)
    4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response.
    4-Thiouridine (Standard)
  • HY-138615A
    Deoxythymidine-5'-triphosphate sodium hydrate
    Deoxythymidine-5'-triphosphate (dTTP) sodium hydrate is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate trisodium salt is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate sodium hydrate
  • HY-171514
    2'-F-CMP
    2'-F-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-F-CMP
  • HY-152710
    5-Methoxycarbonylmethyl-2-thiouridine
    5-Methoxycarbonylmethyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxycarbonylmethyl-2-thiouridine
  • HY-101904
    2-Chloro-2'-deoxycytidine
    2-Chloro-2'-deoxycytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    2-Chloro-2'-deoxycytidine
  • HY-152684
    2′-O-2-Propyn-1-ylguanosine
    2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2′-O-2-Propyn-1-ylguanosine
  • HY-W113081
    4′-Thiouridine
    		98.68%
    4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing.
    4′-Thiouridine
  • HY-112582AGL
    N1-Methylpseudouridine-5′-triphosphate (GMP like)
    N1-Methylpseudouridine-5′-triphosphate (GMP like) (1-Methylpseudouridine-5′-triphosphate (GMP like)) is N1-Methylpseudouridine-5′-triphosphate (HY-112582A) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. N1-Methylpseudouridine-5′-triphosphate (1-Methylpseudouridine-5′-triphosphate) is a nucleobase-modified nucleotide, used for synthesizing mRNA with reduced immunogenicity and improved stability.
    N1-Methylpseudouridine-5′-triphosphate (GMP like)
  • HY-172003
    Isoorotidine
    Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).
    Isoorotidine
  • HY-A0063R
    Tipiracil hydrochloride (Standard)
    		Inhibitor
    Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
    Tipiracil hydrochloride (Standard)
  • HY-177020
    GS-6620 PM
    GS-6620 PM (Compound 2) is an analog of 2′-C-methyl 4-aza-7,9-dideaza adenosine. 2′-C-methyl 4-aza-7,9-dideaza adenosine is an inhibitor of HCV replication in cell culture. GS-6620 PM can be used in the study of hepatitis C virus (HCV) infection.
    GS-6620 PM
  • HY-W726201
    5'-DMT-5-F-2'-dU Phosphoramidite
    		98.0%
    2'-Deoxy-5'-O-DMT-5-fluorouridine 3'-CE phosphoramidite is a nucleoside phosphoramidite analogue employed in oligonucleotide synthesis. This compound contributes to crafting therapeutic oligonucleotides for drugs targeting cancers.
    5'-DMT-5-F-2'-dU Phosphoramidite
  • HY-177198
    5'-DMT-3'-CE-2'-TBDMS 2-cyanoethoxycarbonyl, 2-(4-nitrophenyl)ethyl-guanosine
    5'-DMT-3'-CE-2'-TBDMS 2-cyanoethoxycarbonyl, 2-(4-nitrophenyl)ethyl-guanosine is a nucleotide analogue used in nucleic acid synthesis.
    5'-DMT-3'-CE-2'-TBDMS 2-cyanoethoxycarbonyl, 2-(4-nitrophenyl)ethyl-guanosine
  • HY-171516
    2′-OMe-UMP
    2′-OMe-UMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-UMP
  • HY-171531
    2'-O-MOE-UTP
    2'-O-MOE-UTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-UTP
  • HY-154362A
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate)
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate) (compound 25) displays potent tumor cell growth inhibition activity.
    β-D-Ribofuranose, 3-deoxy-3-fluoro-, 1,2-diacetate 5-(4-methylbenzoate)
  • HY-137701
    ddATPαS
    ddATPαS is a dideoxynucleotide that can be used for DNA sequencing.
    ddATPαS
  • HY-U00130
    1-Acetyl-3-o-toluyl-5-fluorouracil
    1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antitumor agent and a 5-fluorouracil analog.
    1-Acetyl-3-o-toluyl-5-fluorouracil